Benefits of Berberine

I recently saw an article claiming that berberine is a natural Mounjura or Ozempic.  Of course, berberine is far less expensive, so it would be great if it performed just as well for weight loss, but it doesn’t. However, if we only concentrated on weight loss, it would be oversimplifying Berberine and its benefits.  It has been demonstrated in numerous studies to aid in weight loss through a variety of processes, including by assisting the anti-aging enzyme AMPK, which is unquestionably a plus. It also helps with weight reduction by assisting with fat burning and suppressing appetite.

Additionally, I have observed in clinical settings and in the literature that it lowers cholesterol, improves the balance of the gut microbiota, lowers blood sugars, and helps with mild to moderate weight difficulties.  

Berberine provides many more advantages than the latest weight-loss medications, by being more effective compared to those medications in terms of lowering blood cholesterol,  improving gut health and decreasing aging while also helping with blood sugar and weight issues.

Berberine 1-2 capsules with meals is a good start from companies like Douglas, Xymogen and Thorne.

Vitamins for Mental Health

Mood can be addressed with a number of supplements while focusing on a healthy diet and getting enough sleep.   Here are some of my favorites.


The gut proves again that it is the beginning of healing.  Probiotics are very specific, and I would recommend ProbioMood by Pure Encapsulations.  Researched strains that show improved mood are important, and all probiotics are not created equal.

Vitamin D3

Our mood has been unequivocally associated with Vitamin D3 levels.  Getting our levels above 50 ng/dL is essential for good mental health.  Doing this with a trusted source is important, as very few over-the-counter supplements do this right, as such a minute amount is required and easy to get wrong.

Fish Oil (EPA/DHA)

Fish oil works on a lot of important processes in the body but maybe none as important as brain health and mood.  Getting the right kind is important.  It is suspected that a large majority of Americans are deficient in this essential nutrient for mood.


This is one of my all-time favorites when addressing mood with trace mineral amounts like 5-20 mg a day.  Lithium has numerous positive effects, but the brain and mood effects are amazing, as my blog points out.  This is a no-brainer for most people and has been helpful even with people on anti-depressants.

Amino Acids

These are the precursors of our feel-good neurotransmitters, serotonin, and dopamine.  5-HTP is a direct amino acid precursor to serotonin and bypasses a genetic issue in a lot of people that prevents tryptophan from converting to serotonin.  Take 5- HTP with a meal.  L-Tyrosine helps make dopamine which improves energy, focus, and mood.  Take L-Tyrosine away from meals.


A randomized controlled trial published in PLoS ONE in 2017 reported that magnesium supplementation improved symptoms of mild-to-moderate depression in adults, in a similar range as what is seen with the use of antidepressant medications.  Although a small study, it will only help per my clinical experience and I use PowerMag, 2-3 a day.


Having activated folate and other B-vitamins is essential as the body can immediately use them in the essential process of making neurotransmitters.   I do this with a good multivitamin, like PureGenomics Ultramulti, which has lithium, vitamin D3 (4000 IU),  and magnesium as well.  

Addressing past trauma through counseling, sleep, diet, stress, and exercise is also essential as you cannot supplement your way out of a poor lifestyle, but it can help to give you more leverage to improve your mood.